Grand Rounds in Pediatric Nephrology — an ISN-IPNA Sister Centers initiative: Diagnosis and Treatment of Hyperoxaluria Type 1: Old and New, August 11, 2023 - IPNA Online - International Pediatric Nephrology Association (function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer','GTM-5B758VC'); window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-2J0EX6V8BQ');

GREAT CARE FOR LITTLE KIDNEYS. EVERYWHERE.

IPNA Online – International Pediatric Nephrology Association
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Aug 02, 2023

Grand Rounds in Pediatric Nephrology — an ISN-IPNA Sister Centers initiative: Diagnosis and Treatment of Hyperoxaluria Type 1: Old and New, August 11, 2023

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A child presented with a history of multiple kidney stones and end-stage kidney disease. Diagnostic evaluation demonstrated hyperoxaluria type 1. We will review the different clinical scenarios when one should suspect hyperoxaluria type 1 and how to make the diagnosis. Finally, we will discuss therapeutic options, including pyridoxine, liver transplantation and lumasiran, a recent advance in the treatment of hyperoxaluria type 1. 

Learning objectives: 

  • Describe 3 different clinical presentations of hyperoxaluria type 1. 
  • Plan the diagnostic strategy for a patient with suspected hyperoxaluria type 1. 
  • Explain how lumasiran decreases liver oxalate production in hyperoxaluria type 1. 

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