IPNA reviews the best evidence in Pediatric Nephrology to produce or endorse guidelines, providing guidance on the best practices for diagnosing and managing pediatric kidney diseases.



IPNA follows a rigorous process for development of clinical practice guidelines that have relevance and applicability internationally.

List of guidelines

Prepared Guidelines
Endorsed Guidelines
Regional Guidelines

Recommendations for the Diagnosis and Management of Children with Steroid-Resistant Nephrotic Syndrome (SRNS)

Translations available in 14 languages

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IPNA aHUS Guideline in Development

Atypical hemolytic uremic syndrome (aHUS) is a rare, complement-driven thrombotic microangiopathy (TMA).

With the advent of the complement C5 antibody eculizumab, outcomes of aHUS patients have significantly improved including outcomes of patients with kidney transplants.

Given the rarity of aHUS and the resulting lack of randomized controlled trials, international treatment guidelines are currently not available and treatment recommendations are typically based on expert opinion. In addition, access to the prohibitively expensive eculizumab is limited to economically privileged countries thus creating an inacceptable and unjust global imbalance with respect to the management of aHUS patients. On this background and given its focus on the management of rare kidney diseases, IPNA initiated the development of clinical practice recommendations (CPRs) for aHUS. As for other IPNA CPRs, the new aHUS CPR will be developed applying the GRADE approach using PICO (population-intervention-comparator-outcome) questions on diagnosis and treatment of aHUS, will be based on information extracted from the available literature graded by evidence (“evidence tables”), and will eventually be published.